The role of cohesin-mediated loop extrusion in genome organization and gene expression

Bioinformatics and BioComplexity
Online live-streamed seminar - Link below
Dr. Elzo de Wit
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The three-dimensional (3D) organization of the genome inside the nucleus plays a crucial role in essential processes such as DNA replication and gene expression. Genes in multicellular organisms are regulated by genetic elements called enhancers which can be located far away from their target promoter. How these elements can communicate over these large distances is an open question. My lab uses large-scale genomics and computation biology methods to understand how the folding of the genome influences the expression of genes.

About the speaker

Since his PhD Elzo has been fascinated by the organization of DNA and chromatin inside the cell nucleus and how this relates to gene expression. He performed his PhD research in the lab of Bas van Steensel at the NKI. During this period Elzo spent three months as a visiting scientist at Columbia University in New York.

Following his PhD Elzo performed post-doctoral research in the lab of Wouter de Laat at the Hubrecht Institute, where he studied the 3D organization of the genome inside the nucleus. During this period he received a Veni career fellowship from NWO. He was also a co-founder of the biotech company Cergentis, where he served as head of bioinformatics for two days a week, in addition to his post-doctoral research.

In 2015 Elzo joined the Netherlands Cancer Institute as a junior group leader where he lead a joined computational and experimental research group. His research has been awarded with an ERC Starting grand and an NWO Vidi career grant and more recently an ERC Consolidator grant.

Since 2017 he is also a junior group leader at Oncode Institute.

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